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Effects of Copper Chelation on BRAF(V600E) Positive Colon Carcinoma Cells
High affinity copper binding to mitogen-activated protein kinase kinase 1 (MAP2K1, also known as MEK1) allosterically promotes the kinase activity of MEK1/2 on extracellular signal regulated kinases 1 and 2 (ERK1/2). Consequently, copper-dependent activation of the mitogen-activated (MAP) kinase pat...
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| Publicado no: | Cancers (Basel) |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6562624/ https://ncbi.nlm.nih.gov/pubmed/31083627 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11050659 |
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