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Loss of Phd2 cooperates with BRAF(V600E) to drive melanomagenesis
Prolyl hydroxylase domain protein 2 (PHD2) is a well-known master oxygen sensor. However, the role of PHD2 in tumor initiation remains controversial. We find that during the transition of human nevi to melanoma, the expression of PHD2 protein is significantly decreased and lower expression PHD2 in m...
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| Publicado no: | Nat Commun |
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| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6303344/ https://ncbi.nlm.nih.gov/pubmed/30575721 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07126-9 |
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