Loss of Phd2 cooperates with BRAF(V600E) to drive melanomagenesis

Prolyl hydroxylase domain protein 2 (PHD2) is a well-known master oxygen sensor. However, the role of PHD2 in tumor initiation remains controversial. We find that during the transition of human nevi to melanoma, the expression of PHD2 protein is significantly decreased and lower expression PHD2 in m...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Liu, Shujing, Zhang, Gao, Guo, Jianping, Chen, Xiang, Lei, Jingce, Ze, Kan, Dong, Liyun, Dai, Xiangpeng, Gao, Yang, Song, Daisheng, Ecker, Brett L., Yang, Ruifeng, Feltcher, Caitlin, Peng, Kai, Feng, Cheng, Chen, Hui, Lee, Rebecca X., Kerestes, Heddy, Niu, Jingwen, Kumar, Suresh, Xu, Weiting, Zhang, Jie, Wei, Zhi, Martin, James S., Liu, Xiaoming, Mills, Gordon, Lu, Yiling, Guo, Wei, Sun, Lunquan, Zhang, Lin, Weeraratna, Ashani, Herlyn, Meenhard, Wei, Wenyi, Lee, Frank S., Xu, Xiaowei
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6303344/
https://ncbi.nlm.nih.gov/pubmed/30575721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07126-9
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