Loss of Phd2 cooperates with BRAF(V600E) to drive melanomagenesis

Prolyl hydroxylase domain protein 2 (PHD2) is a well-known master oxygen sensor. However, the role of PHD2 in tumor initiation remains controversial. We find that during the transition of human nevi to melanoma, the expression of PHD2 protein is significantly decreased and lower expression PHD2 in m...

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Bibliografiset tiedot
Julkaisussa:Nat Commun
Päätekijät: Liu, Shujing, Zhang, Gao, Guo, Jianping, Chen, Xiang, Lei, Jingce, Ze, Kan, Dong, Liyun, Dai, Xiangpeng, Gao, Yang, Song, Daisheng, Ecker, Brett L., Yang, Ruifeng, Feltcher, Caitlin, Peng, Kai, Feng, Cheng, Chen, Hui, Lee, Rebecca X., Kerestes, Heddy, Niu, Jingwen, Kumar, Suresh, Xu, Weiting, Zhang, Jie, Wei, Zhi, Martin, James S., Liu, Xiaoming, Mills, Gordon, Lu, Yiling, Guo, Wei, Sun, Lunquan, Zhang, Lin, Weeraratna, Ashani, Herlyn, Meenhard, Wei, Wenyi, Lee, Frank S., Xu, Xiaowei
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group UK 2018
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6303344/
https://ncbi.nlm.nih.gov/pubmed/30575721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07126-9
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