Combined menin and EGFR inhibitors synergize to suppress colorectal cancer via EGFR-independent and calcium-mediated repression of SKP2 transcription

Menin is a nuclear epigenetic regulator that can both promote and suppress tumor growth in a highly tissue-specific manner. The role of menin in colorectal cancer (CRC), however, remains unclear. Here we demonstrate that menin was overexpressed in CRC and that inhibition of menin synergized with sma...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cancer Res
Egile Nagusiak: Katona, Bryson W., Glynn, Rebecca A., Paulosky, Kayla E., Feng, Zijie, Davis, Caroline I., Ma, Jian, Berry, Corbett T., Szigety, Katherine M., Matkar, Smita, Liu, Yuanyuan, Wang, Haoren, Wu, Yuan, He, Xin, Freedman, Bruce D., Brady, Donita C., Hua, Xianxin
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2019
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6996413/
https://ncbi.nlm.nih.gov/pubmed/30877106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-18-2133
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