Combined menin and EGFR inhibitors synergize to suppress colorectal cancer via EGFR-independent and calcium-mediated repression of SKP2 transcription

Menin is a nuclear epigenetic regulator that can both promote and suppress tumor growth in a highly tissue-specific manner. The role of menin in colorectal cancer (CRC), however, remains unclear. Here we demonstrate that menin was overexpressed in CRC and that inhibition of menin synergized with sma...

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書誌詳細
出版年:Cancer Res
主要な著者: Katona, Bryson W., Glynn, Rebecca A., Paulosky, Kayla E., Feng, Zijie, Davis, Caroline I., Ma, Jian, Berry, Corbett T., Szigety, Katherine M., Matkar, Smita, Liu, Yuanyuan, Wang, Haoren, Wu, Yuan, He, Xin, Freedman, Bruce D., Brady, Donita C., Hua, Xianxin
フォーマット: Artigo
言語:Inglês
出版事項: 2019
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6996413/
https://ncbi.nlm.nih.gov/pubmed/30877106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-18-2133
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