CDK7 inhibition suppresses Castration-Resistant Prostate Cancer through MED1 inactivation

Metastatic castration-resistant prostate cancer (CRPC) is a fatal disease, primarily resulting from the transcriptional addiction driven by Androgen Receptor (AR). First-line CRPC treatments typically target AR-signaling, but are rapidly bypassed, resulting in only a modest survival benefit with the...

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Detalhes bibliográficos
Publicado no:Cancer Discov
Main Authors: ur Rasool, Reyaz, Natesan, Ramakrishnan, Deng, Qu, Aras, Shweta, Lal, Priti, Sander Effron, Samuel, Mitchell-Velasquez, Erick, Posimo, Jessica M., Carskadon, Shannon, Baca, Sylvan C., Pomerantz, Mark M., Siddiqui, Javed, Schwartz, Lauren E., Lee, Daniel J., Palanisamy, Nallasivam, Narla, Goutham, Den, Robert B., Freedman, Matthew L., Brady, Donita C., Asangani, Irfan A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7202356/
https://ncbi.nlm.nih.gov/pubmed/31466944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-19-0189
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