Targeting the Achilles Heel of Multidrug-Resistant Cancer by Exploiting the Fitness Cost of Resistance

Por Szakács, Gergely, Hall, Matthew D., Gottesman, Michael M., Boumendjel, Ahcène, Kachadourian, Remy, Day, Brian J., Baubichon-Cortay, Hélène, Di Pietro, Attilio
Publicado em 2014

A novel chalcone derivative which acts as a microtubule depolymerising agent and an inhibitor of P-gp and BCRP in in-vitro and in-vivo glioblastoma models

Por Boumendjel, Ahcene, McLeer-Florin, Anne, Champelovier, Pierre, Allegro, Diane, Muhammad, Dima, Souard, Florence, Derouazi, Madiha, Peyrot, Vincent, Toussaint, Bertrand, Boutonnat, Jean
Publicado em 2009

Discovery of naturally occurring aurones that are potent allosteric inhibitors of hepatitis C virus RNA-dependent RNA polymerase

Por Haudecoeur, Romain, Ahmed-Belkacem, Abdelhakim, Yi, Wei, Fortuné, Antoine, Brillet, Rozenn, Belle, Catherine, Nicolle, Edwige, Pallier, Coralie, Pawlotsky, Jean-Michel, Boumendjel, Ahcène
Publicado em 2011

A Synthetic Chalcone as a Potent Inducer of Glutathione Biosynthesis

Por Kachadourian, Remy, Day, Brian J., Pugazhenti, Subbiah, Franklin, Christopher C., Genoux-Bastide, Estelle, Mahaffey, Gregory, Gauthier, Charlotte, Di Pietro, Attilio, Boumendjel, Ahcène
Publicado em 2012

IPP51, a chalcone acting as a microtubule inhibitor with in vivo antitumor activity against bladder carcinoma

Por Martel-Frachet, Véronique, Keramidas, Michelle, Nurisso, Alessandra, DeBonis, Salvatore, Rome, Claire, Coll, Jean-Luc, Boumendjel, Ahcène, Skoufias, Dimitrios A., Ronot, Xavier
Publicado no Oncotarget (2015)

A retro-biosynthetic approach to the prediction of biosynthetic pathways from position-specific isotope analysis as shown for tramadol

Por Romek, Katarzyna M., Nun, Pierrick, Remaud, Gérald S., Silvestre, Virginie, Taïwe, Germain Sotoing, Lecerf-Schmidt, Florine, Boumendjel, Ahcène, De Waard, Michel, Robins, Richard J.
Publicado no Proc Natl Acad Sci U S A (2015)

2-Hydroxypyridine-N-oxide-Embedded Aurones as Potent Human Tyrosinase Inhibitors

Por Haudecoeur, Romain, Carotti, Marcello, Gouron, Aurélie, Maresca, Marc, Buitrago, Elina, Hardré, Renaud, Bergantino, Elisabetta, Jamet, Hélène, Belle, Catherine, Réglier, Marius, Bubacco, Luigi, Boumendjel, Ahcène
Publicado no ACS Med Chem Lett (2016)

Investigation of Chalcones as Selective Inhibitors of the Breast Cancer Resistance Protein: Critical Role of Methoxylation in both Inhibition Potency and Cytotoxicity

Por Valdameri, Glaucio, Gauthier, Charlotte, Terreux, Raphaël, Kachadourian, Rémy, Day, Brian J., Winnischofer, Sheila M. B., Rocha, Maria E. M., Frachet, Véronique, Ronot, Xavier, Di Pietro, Attilio, Boumendjel, Ahcène
Publicado em 2012

MBL-II-141, a chromone derivative, enhances irinotecan (CPT-11) anticancer efficiency in ABCG2-positive xenografts

Por Honorat, Mylène, Guitton, Jérôme, Gauthier, Charlotte, Bouard, Charlotte, Lecerf-Schmidt, Florine, Peres, Basile, Terreux, Raphaël, Gervot, Héloïse, Rioufol, Catherine, Boumendjel, Ahcène, Puisieux, Alain, Di Pietro, Attilio, Payen, Léa
Publicado no Oncotarget (2015)

Dicer-Mediated Upregulation of BCRP Confers Tamoxifen Resistance in Human Breast Cancer Cells

Por Selever, Jennifer, Gu, Guowei, Lewis, Michael T., Beyer, Amanda, Herynk, Matthew H., Covington, Kyle R., Tsimelzon, Anna, Dontu, Gabriela, Provost, Patrick, Di Pietro, Attilio, Boumendjel, Ahcène, Albain, Kathy, Miele, Lucio, Weiss, Heidi, Barone, Ines, Ando, Sebastiano, Fuqua, Suzanne A. W.
Publicado em 2011