2-Hydroxypyridine-N-oxide-Embedded Aurones as Potent Human Tyrosinase Inhibitors

[Image: see text] With the aim to develop effective and selective human tyrosinase inhibitors, we investigated aurone derivatives whose B-ring was replaced by a non-oxidizable 2-hydroxypyridine-N-oxide (HOPNO) moiety. These aurones were synthesized and evaluated as inhibitors of purified human tyros...

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Opis bibliograficzny
Wydane w:ACS Med Chem Lett
Główni autorzy: Haudecoeur, Romain, Carotti, Marcello, Gouron, Aurélie, Maresca, Marc, Buitrago, Elina, Hardré, Renaud, Bergantino, Elisabetta, Jamet, Hélène, Belle, Catherine, Réglier, Marius, Bubacco, Luigi, Boumendjel, Ahcène
Format: Artigo
Język:Inglês
Wydane: American Chemical Society 2016
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5238473/
https://ncbi.nlm.nih.gov/pubmed/28105275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00369
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