Discovery of naturally occurring aurones that are potent allosteric inhibitors of hepatitis C virus RNA-dependent RNA polymerase

We have identified naturally occurring 2-benzylidenebenzofuran-3-ones (aurones) as new templates for non-nucleoside hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp) inhibitors. The aurone target site, identified by site-directed mutagenesis, is located in Thumb Pocket I of HCV RdRp. The R...

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Hauptverfasser: Haudecoeur, Romain, Ahmed-Belkacem, Abdelhakim, Yi, Wei, Fortuné, Antoine, Brillet, Rozenn, Belle, Catherine, Nicolle, Edwige, Pallier, Coralie, Pawlotsky, Jean-Michel, Boumendjel, Ahcène
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3579765/
https://ncbi.nlm.nih.gov/pubmed/21699179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm200242p
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