Inhibition of RNA binding to hepatitis C virus RNA-dependent RNA polymerase: a new mechanism for antiviral intervention

The hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp) is a key target for antiviral intervention. The goal of this study was to identify the binding site and unravel the molecular mechanism by which natural flavonoids efficiently inhibit HCV RdRp. Screening identified the flavonol querceta...

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Detalhes bibliográficos
Main Authors: Ahmed-Belkacem, Abdelhakim, Guichou, Jean-François, Brillet, Rozenn, Ahnou, Nazim, Hernandez, Eva, Pallier, Coralie, Pawlotsky, Jean-Michel
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
Assuntos:
RNA
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4132742/
https://ncbi.nlm.nih.gov/pubmed/25053847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku632
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