Inhibition of RNA binding to hepatitis C virus RNA-dependent RNA polymerase: a new mechanism for antiviral intervention

The hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp) is a key target for antiviral intervention. The goal of this study was to identify the binding site and unravel the molecular mechanism by which natural flavonoids efficiently inhibit HCV RdRp. Screening identified the flavonol querceta...

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Bibliographic Details
Main Authors: Ahmed-Belkacem, Abdelhakim, Guichou, Jean-François, Brillet, Rozenn, Ahnou, Nazim, Hernandez, Eva, Pallier, Coralie, Pawlotsky, Jean-Michel
Format: Artigo
Language:Inglês
Published: Oxford University Press 2014
Subjects:
RNA
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4132742/
https://ncbi.nlm.nih.gov/pubmed/25053847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku632
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