Inhibition of RNA binding to hepatitis C virus RNA-dependent RNA polymerase: a new mechanism for antiviral intervention

The hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp) is a key target for antiviral intervention. The goal of this study was to identify the binding site and unravel the molecular mechanism by which natural flavonoids efficiently inhibit HCV RdRp. Screening identified the flavonol querceta...

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Hlavní autoři: Ahmed-Belkacem, Abdelhakim, Guichou, Jean-François, Brillet, Rozenn, Ahnou, Nazim, Hernandez, Eva, Pallier, Coralie, Pawlotsky, Jean-Michel
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2014
Témata:
RNA
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4132742/
https://ncbi.nlm.nih.gov/pubmed/25053847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku632
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