Characterization of the Anti-Hepatitis C Virus Activity of New Nonpeptidic Small-Molecule Cyclophilin Inhibitors with the Potential for Broad Anti-Flaviviridae Activity

Although members of the Flaviviridae display high incidence, morbidity, and mortality rates, the development of specific antiviral drugs for each virus is unlikely. Cyclophilins, a family of host peptidyl-prolyl cis-trans isomerases (PPIases), play a pivotal role in the life cycles of many viruses a...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Nevers, Quentin, Ruiz, Isaac, Ahnou, Nazim, Donati, Flora, Brillet, Rozenn, Softic, Laurent, Chazal, Maxime, Jouvenet, Nolwenn, Fourati, Slim, Baudesson, Camille, Bruscella, Patrice, Gelin, Muriel, Guichou, Jean-François, Pawlotsky, Jean-Michel, Ahmed-Belkacem, Abdelhakim
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6021681/
https://ncbi.nlm.nih.gov/pubmed/29760125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00126-18
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