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Conformational Flexibility of Human Casein Kinase Catalytic Subunit Explored by Metadynamics
Casein kinase CK2 is an essential enzyme in higher organisms, catalyzing the transfer of the γ phosphate from ATP to serine and threonine residues on protein substrates. In a number of animal tumors, CK2 activity has been shown to escape normal cellular control, making it a potential target for canc...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Biophysical Society
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4026775/ https://ncbi.nlm.nih.gov/pubmed/24606937 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2014.01.031 |
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