Josephin Domain Structural Conformations Explored by Metadynamics in Essential Coordinates

The Josephin Domain (JD), i.e. the N-terminal domain of Ataxin 3 (At3) protein, is an interesting example of competition between physiological function and aggregation risk. In fact, the fibrillogenesis of Ataxin 3, responsible for the spinocerebbellar ataxia 3, is strictly related to the JD thermod...

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Detaylı Bibliyografya
Yayımlandı:PLoS Comput Biol
Asıl Yazarlar: Deriu, Marco A., Grasso, Gianvito, Tuszynski, Jack A., Gallo, Diego, Morbiducci, Umberto, Danani, Andrea
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2016
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4706304/
https://ncbi.nlm.nih.gov/pubmed/26745628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1004699
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