Investigation of the Josephin Domain Protein-Protein Interaction by Molecular Dynamics

Spinocerebellar ataxia (SCA) 3, the most common form of SCA, is a neurodegenerative rare disease characterized by polyglutamine tract expansion and self-assembly of Ataxin3 (At3) misfolded proteins into highly organized fibrillar aggregates. The At3 N-terminal Josephin Domain (JD) has been suggested...

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Main Authors: Deriu, Marco A., Grasso, Gianvito, Licandro, Ginevra, Danani, Andrea, Gallo, Diego, Tuszynski, Jack A., Morbiducci, Umberto
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2014
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4182536/
https://ncbi.nlm.nih.gov/pubmed/25268243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0108677
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