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Destabilizing the AXH Tetramer by Mutations: Mechanisms and Potential Antiaggregation Strategies
The AXH domain of protein Ataxin 1 is thought to play a key role in the misfolding and aggregation pathway responsible for Spinocerebellar ataxia 1. For this reason, a molecular level understanding of AXH oligomerization pathway is crucial to elucidate the aggregation mechanism, which is thought to...
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| Publicado no: | Biophys J |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Biophysical Society
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5984971/ https://ncbi.nlm.nih.gov/pubmed/29401430 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2017.11.025 |
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