The Role of Structural Polymorphism in Driving the Mechanical Performance of the Alzheimer's Beta Amyloid Fibrils

Alzheimer's Disease (AD) is related with the abnormal aggregation of amyloid β-peptides Aβ(1−40) and Aβ(1−42), the latter having a polymorphic character which gives rise to U- or S-shaped fibrils. Elucidating the role played by the nanoscale-material architecture on the amyloid fibril stability...

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Vydáno v:Front Bioeng Biotechnol
Hlavní autoři: Grasso, Gianvito, Rebella, Martina, Morbiducci, Umberto, Tuszynski, Jack A., Danani, Andrea, Deriu, Marco A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2019
Témata:
Bioengineering and Biotechnology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6499180/
https://ncbi.nlm.nih.gov/pubmed/31106199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fbioe.2019.00083
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