Destabilizing the AXH Tetramer by Mutations: Mechanisms and Potential Antiaggregation Strategies

The AXH domain of protein Ataxin 1 is thought to play a key role in the misfolding and aggregation pathway responsible for Spinocerebellar ataxia 1. For this reason, a molecular level understanding of AXH oligomerization pathway is crucial to elucidate the aggregation mechanism, which is thought to...

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Dades bibliogràfiques
Publicat a:Biophys J
Autors principals: Grasso, Gianvito, Morbiducci, Umberto, Massai, Diana, Tuszynski, Jack A., Danani, Andrea, Deriu, Marco A.
Format: Artigo
Idioma:Inglês
Publicat: The Biophysical Society 2018
Matèries:
Proteins
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5984971/
https://ncbi.nlm.nih.gov/pubmed/29401430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2017.11.025
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