A novel chalcone derivative which acts as a microtubule depolymerising agent and an inhibitor of P-gp and BCRP in in-vitro and in-vivo glioblastoma models

BACKGROUND: Over the past decades, in spite of intensive search, no significant increase in the survival of patients with glioblastoma has been obtained. The role of the blood-brain barrier (BBB) and especially the activity of efflux pumps belonging to the ATP Binding Cassette (ABC) family may, in p...

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Detalhes bibliográficos
Main Authors: Boumendjel, Ahcene, McLeer-Florin, Anne, Champelovier, Pierre, Allegro, Diane, Muhammad, Dima, Souard, Florence, Derouazi, Madiha, Peyrot, Vincent, Toussaint, Bertrand, Boutonnat, Jean
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2717121/
https://ncbi.nlm.nih.gov/pubmed/19619277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-9-242
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