Dicer-Mediated Upregulation of BCRP Confers Tamoxifen Resistance in Human Breast Cancer Cells

PURPOSE: Tamoxifen (Tam) is the most prescribed hormonal agent for treatment of estrogen receptor α-positive breast cancer patients. Using microarray analysis, we observed that metastatic breast tumors resistant to Tam therapy had elevated levels of Dicer. EXPERIMENTAL DESIGN: We overexpressed Dicer...

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Bibliografische gegevens
Hoofdauteurs: Selever, Jennifer, Gu, Guowei, Lewis, Michael T., Beyer, Amanda, Herynk, Matthew H., Covington, Kyle R., Tsimelzon, Anna, Dontu, Gabriela, Provost, Patrick, Di Pietro, Attilio, Boumendjel, Ahcène, Albain, Kathy, Miele, Lucio, Weiss, Heidi, Barone, Ines, Ando, Sebastiano, Fuqua, Suzanne A. W.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2011
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3281508/
https://ncbi.nlm.nih.gov/pubmed/21878538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-11-1403
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