Phosphorylation of the Mutant K303R Estrogen Receptor α at Serine 305 Impacts Aromatase Inhibitor Sensitivity

We previously identified a lysine to arginine transition at residue 303 (K303R) in ERα in invasive breast cancers, which confers resistance to the aromatase inhibitor (AI) anastrozole (Ana) when expressed in MCF-7 breast cancer cells. Here we show that AI resistance arises through an enhanced cross-...

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Main Authors: Barone, Ines, Iacopetta, Domenico, Covington, Kyle R., Cui, Yukun, Anna, Tsimelzon, Beyer, Amanda, Andò, Sebastiano, Fuqua, Suzanne A. W.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2922934/
https://ncbi.nlm.nih.gov/pubmed/20101208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2009.520
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