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Growth Factor-Induced Resistance to Tamoxifen is Associated with a Mutation of Estrogen Receptor α and its Phosphorylation at Serine 305

Estrogens play a crucial role in breast tumor growth, which is the rationale for the use of antiestrogens, such as tamoxifen, in women with estrogen receptor (ER)-α-positive breast cancer. However hormone resistance is a major clinical problem. Altered growth factor signaling to the ERα pathway has...

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Vydáno v:Breast Cancer Res Treat
Hlavní autoři: Giordano, Cinzia, Cui, Yukun, Barone, Ines, Ando, Sebastiano, Mancini, Michael A, Berno, Valeria, Fuqua, Suzanne A.W.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4482256/
https://ncbi.nlm.nih.gov/pubmed/19205871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10549-009-0334-0
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