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Insights into how phosphorylation of estrogen receptor at serine 305 modulates tamoxifen activity in breast cancer

Estrogen receptor (ER) is the most important factor in the pathophysiology of breast cancer. Consequently, modulation of ER activity has been exploited to develop drugs against ER+ breast cancer, such as tamoxifen, referred to as endocrine therapies. With deeper understanding of ER mechanism of acti...

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Publicat a:Mol Cell Endocrinol
Autors principals: Kastrati, Irida, Semina, Svetlana, Gordon, Benjamin, Smart, Emily
Format: Artigo
Idioma:Inglês
Publicat: 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6368394/
https://ncbi.nlm.nih.gov/pubmed/30659843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mce.2019.01.014
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