Identifying Cancer-Relevant Mutations in the DLC START Domain Using Evolutionary and Structure-Function Analyses

par Holub, Ashton S., Bouley, Renee A., Petreaca, Ruben C., Husbands, Aman Y.
Publié dans Int J Mol Sci (2020)

Exploration of mild copper-mediated coupling of organotrifluoroborates in the synthesis of thiirane-based inhibitors of matrix metalloproteinases

par Testero, Sebastian A., Bouley, Renee, Fisher, Jed F., Chang, Mayland, Mobashery, Shahriar
Publié 2010

Structural basis of lysosomal phospholipase A(2) inhibition by Zn(2+)

par Bouley, Renee A., Hinkovska-Galcheva, Vania, Shayman, James A., Tesmer, John J. G.
Publié dans Biochemistry (2019)

Utilizing a Structure-Based Docking Approach to Develop Potent G Protein-Coupled Receptor Kinase (GRK) 2 and 5 Inhibitors

par Waldschmidt, Helen V., Bouley, Renee, Kirchhoff, Paul D., Lee, Pil, Tesmer, John J. G., Larsen, Scott D.
Publié dans Bioorg Med Chem Lett (2018)

Synthesis and Evaluation of 1,2,4-Triazolo[1,5-a]pyrimidines as Antibacterial Agents Against Enterococcus faecium

par Wang, Huan, Lee, Mijoon, Peng, Zhihong, Blázquez, Blas, Lastochkin, Elena, Kumarasiri, Malika, Bouley, Renee, Chang, Mayland, Mobashery, Shahriar
Publié dans J Med Chem (2015)

Generation of Highly Selective, Potent, and Covalent G Protein-Coupled Receptor Kinase 5 Inhibitors

par Rowlands, Rachel A., Chen, Qiuyan, Bouley, Renee A., Avramova, Larisa V., Tesmer, John J. G., White, Andrew D.
Publié dans J Med Chem (2021)

Conformational dynamics in penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus, allosteric communication network and enablement of catalysis

par Mahasenan, Kiran V., Molina, Rafael, Bouley, Renee, Batuecas, María T., Fisher, Jed F., Hermoso, Juan A., Chang, Mayland, Mobashery, Shahriar
Publié dans J Am Chem Soc (2017)

Determinants of pH profile and acyl chain selectivity in lysosomal phospholipase A(2)

par Hinkovska-Galcheva, Vania, Kelly, Robert, Manthei, Kelly A., Bouley, Renee, Yuan, Wenmin, Schwendeman, Anna, Tesmer, John J. G., Shayman, James A.
Publié dans J Lipid Res (2018)

A New Paroxetine-Based GRK2 Inhibitor Reduces Internalization of the μ-Opioid Receptor

par Bouley, Renee A., Weinberg, Zara Y., Waldschmidt, Helen V., Yen, Yu-Chen, Larsen, Scott D., Puthenveedu, Manojkumar A., Tesmer, John J.G.
Publié dans Mol Pharmacol (2020)

Structure–Activity Relationship for the 4(3H)-Quinazolinone Antibacterials

par Bouley, Renee, Ding, Derong, Peng, Zhihong, Bastian, Maria, Lastochkin, Elena, Song, Wei, Suckow, Mark A., Schroeder, Valerie A., Wolter, William R., Mobashery, Shahriar, Chang, Mayland
Publié dans J Med Chem (2016)

Structure-Based Design of Selective, Covalent G Protein-Coupled Receptor Kinase 5 Inhibitors

par Rowlands, Rachel A., Cato, M. Claire, Waldschmidt, Helen V., Bouley, Renee A., Chen, Qiuyan, Avramova, Larisa, Larsen, Scott D., Tesmer, John J. G., White, Andrew D.
Publié dans ACS Med Chem Lett (2019)

Structural Determinants Influencing the Potency and Selectivity of Indazole-Paroxetine Hybrid G Protein–Coupled Receptor Kinase 2 Inhibitors

par Bouley, Renee, Waldschmidt, Helen V., Cato, M. Claire, Cannavo, Alessandro, Song, Jianliang, Cheung, Joseph Y., Yao, Xin-Qiu, Koch, Walter J., Larsen, Scott D., Tesmer, John J. G.
Publié dans Mol Pharmacol (2017)

Synergistic, collaterally sensitive β-lactam combinations suppress resistance in MRSA

par Gonzales, Patrick R., Pesesky, Mitchell W., Bouley, Renee, Ballard, Anna, Biddy, Brent A., Suckow, Mark A., Wolter, William R., Schroeder, Valerie A., Burnham, Carey-Ann D., Mobashery, Shahriar, Chang, Mayland, Dantas, Gautam
Publié dans Nat Chem Biol (2015)

The Quinazolinone Allosteric Inhibitor of PBP 2a Synergizes with Piperacillin and Tazobactam against Methicillin-Resistant Staphylococcus aureus

par Janardhanan, Jeshina, Bouley, Renee, Martínez-Caballero, Siseth, Peng, Zhihong, Batuecas-Mordillo, Mayte, Meisel, Jayda E., Ding, Derong, Schroeder, Valerie A., Wolter, William R., Mahasenan, Kiran V., Hermoso, Juan A., Mobashery, Shahriar, Chang, Mayland
Publié dans Antimicrob Agents Chemother (2019)

Discovery of Antibiotic (E)-3-(3-Carboxyphenyl)-2-(4-cyanostyryl)quinazolin-4(3H)-one

par Bouley, Renee, Kumarasiri, Malika, Peng, Zhihong, Otero, Lisandro H., Song, Wei, Suckow, Mark A., Schroeder, Valerie A., Wolter, William R., Lastochkin, Elena, Antunes, Nuno T., Pi, Hualiang, Vakulenko, Sergei, Hermoso, Juan A., Chang, Mayland, Mobashery, Shahriar
Publié dans J Am Chem Soc (2015)