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Structural basis of lysosomal phospholipase A(2) inhibition by Zn(2+)
Lysosomal phospholipase A(2) (LPLA(2)/PLA2G15) is a key enzyme involved in lipid homeostasis and is characterized by both phospholipase A2 and transacylase activity, and an acidic pH optimum. Divalent cations such as Ca(2+) and Mg(2+) have previously been shown to have little effect on the activity...
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| Gepubliceerd in: | Biochemistry |
|---|---|
| Hoofdauteurs: | , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2019
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6677152/ https://ncbi.nlm.nih.gov/pubmed/30830753 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.8b01124 |
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