Identifying Cancer-Relevant Mutations in the DLC START Domain Using Evolutionary and Structure-Function Analyses

Por Holub, Ashton S., Bouley, Renee A., Petreaca, Ruben C., Husbands, Aman Y.
Publicado no Int J Mol Sci (2020)

Exploration of mild copper-mediated coupling of organotrifluoroborates in the synthesis of thiirane-based inhibitors of matrix metalloproteinases

Por Testero, Sebastian A., Bouley, Renee, Fisher, Jed F., Chang, Mayland, Mobashery, Shahriar
Publicado em 2010

Structural basis of lysosomal phospholipase A(2) inhibition by Zn(2+)

Por Bouley, Renee A., Hinkovska-Galcheva, Vania, Shayman, James A., Tesmer, John J. G.
Publicado no Biochemistry (2019)

Utilizing a Structure-Based Docking Approach to Develop Potent G Protein-Coupled Receptor Kinase (GRK) 2 and 5 Inhibitors

Por Waldschmidt, Helen V., Bouley, Renee, Kirchhoff, Paul D., Lee, Pil, Tesmer, John J. G., Larsen, Scott D.
Publicado no Bioorg Med Chem Lett (2018)

Synthesis and Evaluation of 1,2,4-Triazolo[1,5-a]pyrimidines as Antibacterial Agents Against Enterococcus faecium

Por Wang, Huan, Lee, Mijoon, Peng, Zhihong, Blázquez, Blas, Lastochkin, Elena, Kumarasiri, Malika, Bouley, Renee, Chang, Mayland, Mobashery, Shahriar
Publicado no J Med Chem (2015)

Generation of Highly Selective, Potent, and Covalent G Protein-Coupled Receptor Kinase 5 Inhibitors

Por Rowlands, Rachel A., Chen, Qiuyan, Bouley, Renee A., Avramova, Larisa V., Tesmer, John J. G., White, Andrew D.
Publicado no J Med Chem (2021)

Conformational dynamics in penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus, allosteric communication network and enablement of catalysis

Por Mahasenan, Kiran V., Molina, Rafael, Bouley, Renee, Batuecas, María T., Fisher, Jed F., Hermoso, Juan A., Chang, Mayland, Mobashery, Shahriar
Publicado no J Am Chem Soc (2017)

Determinants of pH profile and acyl chain selectivity in lysosomal phospholipase A(2)

Por Hinkovska-Galcheva, Vania, Kelly, Robert, Manthei, Kelly A., Bouley, Renee, Yuan, Wenmin, Schwendeman, Anna, Tesmer, John J. G., Shayman, James A.
Publicado no J Lipid Res (2018)

A New Paroxetine-Based GRK2 Inhibitor Reduces Internalization of the μ-Opioid Receptor

Por Bouley, Renee A., Weinberg, Zara Y., Waldschmidt, Helen V., Yen, Yu-Chen, Larsen, Scott D., Puthenveedu, Manojkumar A., Tesmer, John J.G.
Publicado no Mol Pharmacol (2020)

Structure–Activity Relationship for the 4(3H)-Quinazolinone Antibacterials

Por Bouley, Renee, Ding, Derong, Peng, Zhihong, Bastian, Maria, Lastochkin, Elena, Song, Wei, Suckow, Mark A., Schroeder, Valerie A., Wolter, William R., Mobashery, Shahriar, Chang, Mayland
Publicado no J Med Chem (2016)

Structure-Based Design of Selective, Covalent G Protein-Coupled Receptor Kinase 5 Inhibitors

Por Rowlands, Rachel A., Cato, M. Claire, Waldschmidt, Helen V., Bouley, Renee A., Chen, Qiuyan, Avramova, Larisa, Larsen, Scott D., Tesmer, John J. G., White, Andrew D.
Publicado no ACS Med Chem Lett (2019)

Structural Determinants Influencing the Potency and Selectivity of Indazole-Paroxetine Hybrid G Protein–Coupled Receptor Kinase 2 Inhibitors

Por Bouley, Renee, Waldschmidt, Helen V., Cato, M. Claire, Cannavo, Alessandro, Song, Jianliang, Cheung, Joseph Y., Yao, Xin-Qiu, Koch, Walter J., Larsen, Scott D., Tesmer, John J. G.
Publicado no Mol Pharmacol (2017)

Synergistic, collaterally sensitive β-lactam combinations suppress resistance in MRSA

Por Gonzales, Patrick R., Pesesky, Mitchell W., Bouley, Renee, Ballard, Anna, Biddy, Brent A., Suckow, Mark A., Wolter, William R., Schroeder, Valerie A., Burnham, Carey-Ann D., Mobashery, Shahriar, Chang, Mayland, Dantas, Gautam
Publicado no Nat Chem Biol (2015)

The Quinazolinone Allosteric Inhibitor of PBP 2a Synergizes with Piperacillin and Tazobactam against Methicillin-Resistant Staphylococcus aureus

Por Janardhanan, Jeshina, Bouley, Renee, Martínez-Caballero, Siseth, Peng, Zhihong, Batuecas-Mordillo, Mayte, Meisel, Jayda E., Ding, Derong, Schroeder, Valerie A., Wolter, William R., Mahasenan, Kiran V., Hermoso, Juan A., Mobashery, Shahriar, Chang, Mayland
Publicado no Antimicrob Agents Chemother (2019)

Discovery of Antibiotic (E)-3-(3-Carboxyphenyl)-2-(4-cyanostyryl)quinazolin-4(3H)-one

Por Bouley, Renee, Kumarasiri, Malika, Peng, Zhihong, Otero, Lisandro H., Song, Wei, Suckow, Mark A., Schroeder, Valerie A., Wolter, William R., Lastochkin, Elena, Antunes, Nuno T., Pi, Hualiang, Vakulenko, Sergei, Hermoso, Juan A., Chang, Mayland, Mobashery, Shahriar
Publicado no J Am Chem Soc (2015)