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A New Paroxetine-Based GRK2 Inhibitor Reduces Internalization of the μ-Opioid Receptor
G protein-coupled receptor (GPCR) kinases (GRKs) play a key role in terminating signals initiated by agonist-bound GPCRs. However, chronic stimulation of GPCRs, such as that which occurs during heart failure, leads to the overexpression of GRKs and maladaptive downregulation of GPCRs on the cell sur...
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| Izdano u: | Mol Pharmacol |
|---|---|
| Glavni autori: | , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
The American Society for Pharmacology and Experimental Therapeutics
2020
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7237867/ https://ncbi.nlm.nih.gov/pubmed/32234810 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.119.118661 |
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