Emerging evidence of a link between the polycystins and the mTOR pathways

Tekijä Boletta, Alessandra
Julkaistu 2009

Slowing Polycystic Kidney Disease by Fasting

Tekijä Boletta, Alessandra
Julkaisussa J Am Soc Nephrol (2016)

mTORC1-driven accumulation of the oncometabolite fumarate as a potential critical step in renal cancer progression

Tekijä Drusian, Luca, Boletta, Alessandra
Julkaisussa Mol Cell Oncol (2018)

Role of the KEAP1-NRF2 Axis in Renal Cell Carcinoma

Tekijä Clerici, Sara, Boletta, Alessandra
Julkaisussa Cancers (Basel) (2020)

Role of the Polycystins in Cell Migration, Polarity, and Tissue Morphogenesis

Tekijä Nigro, Elisa Agnese, Castelli, Maddalena, Boletta, Alessandra
Julkaisussa Cells (2015)

A Novel Mouse Model Reveals that Polycystin-1 Deficiency in Ependyma and Choroid Plexus Results in Dysfunctional Cilia and Hydrocephalus

Tekijä Wodarczyk, Claas, Rowe, Isaline, Chiaravalli, Marco, Pema, Monika, Qian, Feng, Boletta, Alessandra
Julkaistu 2009

Impaired glomerulogenesis and endothelial cell migration in Pkd1-deficient renal organ cultures

Tekijä Rowe, Isaline, Chiaravalli, Marco, Piontek, Klaus B., Germino, Gregory G., Boletta, Alessandra
Julkaistu 2014

Mechanosensory Genes Pkd1 and Pkd2 Contribute to the Planar Polarization of Brain Ventricular Epithelium

Tekijä Herranz-Pérez, Vicente, Boletta, Alessandra, García-Verdugo, José Manuel, Álvarez-Buylla, Arturo
Julkaisussa J Neurosci (2015)

Polycystin-1 Induces Resistance to Apoptosis through the Phosphatidylinositol 3-Kinase/Akt Signaling Pathway

Tekijä Boca, Manila, Distefano, Gianfranco, Boletta, Alessandra, Qian, Feng, Bhunia, Anil K., Germino, Gregory G.
Julkaistu 2006

Polycystin-1 Induces Cell Migration by Regulating Phosphatidylinositol 3-kinase-dependent Cytoskeletal Rearrangements and GSK3β-dependent Cell–Cell Mechanical Adhesion

Tekijä Boca, Manila, D'Amato, Lisa, Distefano, Gianfranco, Polishchuk, Roman S., Germino, Gregory G., Boletta, Alessandra
Julkaistu 2007

mTORC1 signaling and primary cilia are required for brain ventricle morphogenesis

Tekijä Foerster, Philippe, Daclin, Marie, Asm, Shihavuddin, Faucourt, Marion, Boletta, Alessandra, Genovesio, Auguste, Spassky, Nathalie
Julkaisussa Development (2017)

Polycystin-1 Negatively Regulates Polycystin-2 Expression via the Aggresome/Autophagosome Pathway

Tekijä Cebotaru, Valeriu, Cebotaru, Liudmila, Kim, Hyunho, Chiaravalli, Marco, Boletta, Alessandra, Qian, Feng, Guggino, William B.
Julkaistu 2014

Regulation of the microtubular cytoskeleton by Polycystin-1 favors focal adhesions turnover to modulate cell adhesion and migration

Tekijä Castelli, Maddalena, De Pascalis, Chiara, Distefano, Gianfranco, Ducano, Nadia, Oldani, Amanda, Lanzetti, Letizia, Boletta, Alessandra
Julkaisussa BMC Cell Biol (2015)

Polycystin-1 Binds Par3/aPKC and Controls Convergent Extension During Renal Tubular Morphogenesis

Tekijä Castelli, Maddalena, Boca, Manila, Chiaravalli, Marco, Ramalingam, Harini, Rowe, Isaline, Distefano, Gianfranco, Carroll, Thomas, Boletta, Alessandra
Julkaistu 2013

Identification of a Polycystin-1 Cleavage Product, P100, That Regulates Store Operated Ca(2+) Entry through Interactions with STIM1

Tekijä Woodward, Owen M., Li, Yun, Yu, Shengqiang, Greenwell, Patrick, Wodarczyk, Claas, Boletta, Alessandra, Guggino, William B., Qian, Feng
Julkaistu 2010

Polycystin-1 Regulates Actomyosin Contraction and the Cellular Response to Extracellular Stiffness

Tekijä Nigro, Elisa Agnese, Distefano, Gianfranco, Chiaravalli, Marco, Matafora, Vittoria, Castelli, Maddalena, Pesenti Gritti, Angela, Bachi, Angela, Boletta, Alessandra
Julkaisussa Sci Rep (2019)

Novel Functional Complexity of Polycystin-1 by GPS Cleavage In Vivo: Role in Polycystic Kidney Disease

Tekijä Kurbegovic, Almira, Kim, Hyunho, Xu, Hangxue, Yu, Shengqiang, Cruanès, Julie, Maser, Robin L., Boletta, Alessandra, Trudel, Marie, Qian, Feng
Julkaistu 2014

mTORC1-mediated inhibition of polycystin-1 expression drives renal cyst formation in tuberous sclerosis complex

Tekijä Pema, Monika, Drusian, Luca, Chiaravalli, Marco, Castelli, Maddalena, Yao, Qin, Ricciardi, Sara, Somlo, Stefan, Qian, Feng, Biffo, Stefano, Boletta, Alessandra
Julkaisussa Nat Commun (2016)

Polycystin-1 Regulates Extracellular Signal-Regulated Kinase-Dependent Phosphorylation of Tuberin To Control Cell Size through mTOR and Its Downstream Effectors S6K and 4EBP1

Tekijä Distefano, Gianfranco, Boca, Manila, Rowe, Isaline, Wodarczyk, Claas, Ma, Li, Piontek, Klaus B., Germino, Gregory G., Pandolfi, Pier Paolo, Boletta, Alessandra
Julkaistu 2009

Double inhibition of cAMP and mTOR signalling may potentiate the reduction of cell growth in ADPKD cells

Tekijä de Stephanis, Lucia, Bonon, Anna, Varani, Katia, Lanza, Giovanni, Gafà, Roberta, Pinton, Paolo, Pema, Monika, Somlo, Stefan, Boletta, Alessandra, Aguiari, Gianluca
Julkaisussa Clin Exp Nephrol (2016)