Emerging evidence of a link between the polycystins and the mTOR pathways

von Boletta, Alessandra
Veröffentlicht 2009

Slowing Polycystic Kidney Disease by Fasting

von Boletta, Alessandra
Veröffentlicht in J Am Soc Nephrol (2016)

mTORC1-driven accumulation of the oncometabolite fumarate as a potential critical step in renal cancer progression

von Drusian, Luca, Boletta, Alessandra
Veröffentlicht in Mol Cell Oncol (2018)

Role of the KEAP1-NRF2 Axis in Renal Cell Carcinoma

von Clerici, Sara, Boletta, Alessandra
Veröffentlicht in Cancers (Basel) (2020)

Role of the Polycystins in Cell Migration, Polarity, and Tissue Morphogenesis

von Nigro, Elisa Agnese, Castelli, Maddalena, Boletta, Alessandra
Veröffentlicht in Cells (2015)

A Novel Mouse Model Reveals that Polycystin-1 Deficiency in Ependyma and Choroid Plexus Results in Dysfunctional Cilia and Hydrocephalus

von Wodarczyk, Claas, Rowe, Isaline, Chiaravalli, Marco, Pema, Monika, Qian, Feng, Boletta, Alessandra
Veröffentlicht 2009

Impaired glomerulogenesis and endothelial cell migration in Pkd1-deficient renal organ cultures

von Rowe, Isaline, Chiaravalli, Marco, Piontek, Klaus B., Germino, Gregory G., Boletta, Alessandra
Veröffentlicht 2014

Mechanosensory Genes Pkd1 and Pkd2 Contribute to the Planar Polarization of Brain Ventricular Epithelium

von Herranz-Pérez, Vicente, Boletta, Alessandra, García-Verdugo, José Manuel, Álvarez-Buylla, Arturo
Veröffentlicht in J Neurosci (2015)

Polycystin-1 Induces Resistance to Apoptosis through the Phosphatidylinositol 3-Kinase/Akt Signaling Pathway

von Boca, Manila, Distefano, Gianfranco, Boletta, Alessandra, Qian, Feng, Bhunia, Anil K., Germino, Gregory G.
Veröffentlicht 2006

Polycystin-1 Induces Cell Migration by Regulating Phosphatidylinositol 3-kinase-dependent Cytoskeletal Rearrangements and GSK3β-dependent Cell–Cell Mechanical Adhesion

von Boca, Manila, D'Amato, Lisa, Distefano, Gianfranco, Polishchuk, Roman S., Germino, Gregory G., Boletta, Alessandra
Veröffentlicht 2007

mTORC1 signaling and primary cilia are required for brain ventricle morphogenesis

von Foerster, Philippe, Daclin, Marie, Asm, Shihavuddin, Faucourt, Marion, Boletta, Alessandra, Genovesio, Auguste, Spassky, Nathalie
Veröffentlicht in Development (2017)

Polycystin-1 Negatively Regulates Polycystin-2 Expression via the Aggresome/Autophagosome Pathway

von Cebotaru, Valeriu, Cebotaru, Liudmila, Kim, Hyunho, Chiaravalli, Marco, Boletta, Alessandra, Qian, Feng, Guggino, William B.
Veröffentlicht 2014

Regulation of the microtubular cytoskeleton by Polycystin-1 favors focal adhesions turnover to modulate cell adhesion and migration

von Castelli, Maddalena, De Pascalis, Chiara, Distefano, Gianfranco, Ducano, Nadia, Oldani, Amanda, Lanzetti, Letizia, Boletta, Alessandra
Veröffentlicht in BMC Cell Biol (2015)

Polycystin-1 Binds Par3/aPKC and Controls Convergent Extension During Renal Tubular Morphogenesis

von Castelli, Maddalena, Boca, Manila, Chiaravalli, Marco, Ramalingam, Harini, Rowe, Isaline, Distefano, Gianfranco, Carroll, Thomas, Boletta, Alessandra
Veröffentlicht 2013

Identification of a Polycystin-1 Cleavage Product, P100, That Regulates Store Operated Ca(2+) Entry through Interactions with STIM1

von Woodward, Owen M., Li, Yun, Yu, Shengqiang, Greenwell, Patrick, Wodarczyk, Claas, Boletta, Alessandra, Guggino, William B., Qian, Feng
Veröffentlicht 2010

Polycystin-1 Regulates Actomyosin Contraction and the Cellular Response to Extracellular Stiffness

von Nigro, Elisa Agnese, Distefano, Gianfranco, Chiaravalli, Marco, Matafora, Vittoria, Castelli, Maddalena, Pesenti Gritti, Angela, Bachi, Angela, Boletta, Alessandra
Veröffentlicht in Sci Rep (2019)

Novel Functional Complexity of Polycystin-1 by GPS Cleavage In Vivo: Role in Polycystic Kidney Disease

von Kurbegovic, Almira, Kim, Hyunho, Xu, Hangxue, Yu, Shengqiang, Cruanès, Julie, Maser, Robin L., Boletta, Alessandra, Trudel, Marie, Qian, Feng
Veröffentlicht 2014

mTORC1-mediated inhibition of polycystin-1 expression drives renal cyst formation in tuberous sclerosis complex

von Pema, Monika, Drusian, Luca, Chiaravalli, Marco, Castelli, Maddalena, Yao, Qin, Ricciardi, Sara, Somlo, Stefan, Qian, Feng, Biffo, Stefano, Boletta, Alessandra
Veröffentlicht in Nat Commun (2016)

Polycystin-1 Regulates Extracellular Signal-Regulated Kinase-Dependent Phosphorylation of Tuberin To Control Cell Size through mTOR and Its Downstream Effectors S6K and 4EBP1

von Distefano, Gianfranco, Boca, Manila, Rowe, Isaline, Wodarczyk, Claas, Ma, Li, Piontek, Klaus B., Germino, Gregory G., Pandolfi, Pier Paolo, Boletta, Alessandra
Veröffentlicht 2009

Double inhibition of cAMP and mTOR signalling may potentiate the reduction of cell growth in ADPKD cells

von de Stephanis, Lucia, Bonon, Anna, Varani, Katia, Lanza, Giovanni, Gafà, Roberta, Pinton, Paolo, Pema, Monika, Somlo, Stefan, Boletta, Alessandra, Aguiari, Gianluca
Veröffentlicht in Clin Exp Nephrol (2016)