Exploiting Enzymatic Dynamic Reductive Kinetic Resolution (DYRKR) in Stereocontrolled Synthesis

Por Applegate, Gregory A., Berkowitz, David B.
Publicado no Adv Synth Catal (2015)

A Formal [3,3]-Sigmatropic Rearrangement Route to Quaternary α-Vinyl Amino Acids: Use of Allylic N-PMP Trifluoroacetimidates

Por Berkowitz, David B., Wu, Bin, Li, Huijie
Publicado em 2006

Unleashing a “True” pSer-Mimic in the Cell

Por Panigrahi, Kaushik, Nelson, David L., Berkowitz, David B.
Publicado no Chem Biol (2012)

Halocarbocyclization Entry into the Oxabicyclo[4.3.1]decyl Exomethylene-δ-Lactone Cores of Linearifolin and Zaluzanin A - Exploiting Combinatorial Catalysis

Por Ginotra, Sandeep K., Friest, Jacob A., Berkowitz, David B.
Publicado em 2012

Combining a Clostridial Enzyme Exhibiting Unusual Active Site Plasticity with a Remarkably Facile Sigmatropic Rearrangement: Rapid, Stereocontrolled Entry into Densely Functionaliz...

Por Panigrahi, Kaushik, Applegate, Gregory A., Malik, Guillaume, Berkowitz, David B.
Publicado no J Am Chem Soc (2015)

Combinatorial Catalysis Assisted by a Visible Enzymatic Beacon in Real Time: New Synthetically Versatile (Pseudo)Halometalation/Carbocyclizations

Por Friest, Jacob A., Broussy, Sylvain, Chung, Woo Jin, Berkowitz, David B.
Publicado em 2011

A Set of Phosphatase-Inert “Molecular Rulers” to Probe for Bivalent Mannose 6-Phosphate Ligand-Receptor Interactions

Por Fei, Xiang, Connelly, Christopher M., MacDonald, Richard G., Berkowitz, David B.
Publicado em 2007

Use of a Robust Dehydrogenase from an Archael Hyperthermophile in Asymmetric Catalysis−Dynamic Reductive Kinetic Resolution Entry into (S)-Profens

Por Friest, Jacob A., Maezato, Yukari, Broussy, Sylvain, Blum, Paul, Berkowitz, David B.
Publicado em 2010

A New Dehydrogenase from Clostridium acetobutylicum for Asymmetric Synthesis: Dynamic Reductive Kinetic Resolution Entry into the Taxotère Side Chain

Por Applegate, Gregory A., Cheloha, Ross W., Nelson, David L., Berkowitz, David B.
Publicado no Chem Commun (Camb) (2010)

The α,α-Difluorinated Phosphonate L-pSer-Analogue: An Accessible Chemical Tool for Studying Kinase-Dependent Signal Transduction in Vitro, and In Living Cells

Por Panigrahi, Kaushik, Eggen, MariJean, Maeng, Jun-Ho, Shen, Quanrong, Berkowitz, David B.
Publicado em 2009

Examination of the New α-(2′Z-Fluoro)vinyl Trigger with Lysine Decarboxylase: The Absolute Stereochemistry Dictates the Reaction Course

Por Karukurichi, Kannan R., de la Salud-Bea, Roberto, Jahng, Wan Jin, Berkowitz, David B.
Publicado em 2007

A useful methoxyvinyl cation equivalent: α-t-butyldimethylsilyl-α-methoxyacetaldehyde

Por McCune, Christopher D., Beio, Matthew L., Friest, Jacob A., Ginotra, Sandeep, Berkowitz, David B.
Publicado no Tetrahedron Lett (2015)

Use of Fluorinated Functionality in Enzyme Inhibitor Development: Mechanistic and Analytical Advantages

Por Berkowitz, David B., Karukurichi, Kannan R., de la Salud-Bea, Roberto, Nelson, David L., McCune, Christopher D.
Publicado em 2008

Topoisomerase II-Drug Interaction Domains: Identification of Substituents on Etoposide that Interact with the Enzyme

Por Wilstermann, Amy M., Bender, Ryan P., Godfrey, Murrell, Choi, Sungjo, Anklin, Clemens, Berkowitz, David B., Osheroff, Neil, Graves, David E.
Publicado em 2007

Mini-ISES identifies promising carbafructopyranose-based salens for asymmetric catalysis: Tuning ligand shape via the anomeric effect

Por Karukurichi, Kannan R., Fei, Xiang, Swyka, Robert A., Broussy, Sylvain, Shen, Weijun, Dey, Sangeeta, Roy, Sandip K., Berkowitz, David B.
Publicado no Sci Adv (2015)

Phosphatase-Inert Glucosamine 6-Phosphate Mimics Serve as Actuators of the glmS Riboswitch

Por Fei, Xiang, Holmes, Thomas, Diddle, Julianna, Hintz, Lauren, Delaney, Dan, Stock, Alex, Renner, Danielle, McDevitt, Molly, Berkowitz, David B., Soukup, Juliane K.
Publicado no ACS Chem Biol (2014)

Atomic details of near-transition state conformers for enzyme phosphoryl transfer revealed by [Formula: see text] rather than by phosphoranes

Por Baxter, Nicola J., Bowler, Matthew W., Alizadeh, Tooba, Cliff, Matthew J., Hounslow, Andrea M., Wu, Bin, Berkowitz, David B., Williams, Nicholas H., Blackburn, G. Michael, Waltho, Jonathan P.
Publicado em 2010

“Zipped Synthesis” by Cross-Metathesis Provides a Cystathionine β-Synthase Inhibitor that Attenuates Cellular H(2)S Levels and Reduces Neuronal Infarction in a Rat Ischemic Stroke...

Por McCune, Christopher D., Chan, Su Jing, Beio, Matthew L., Shen, Weijun, Chung, Woo Jin, Szczesniak, Laura M., Chai, Chou, Koh, Shu Qing, Wong, Peter T.-H., Berkowitz, David B.
Publicado no ACS Cent Sci (2016)