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A Set of Phosphatase-Inert “Molecular Rulers” to Probe for Bivalent Mannose 6-Phosphate Ligand-Receptor Interactions
A set of bivalent mannose 6-phosphonate “molecular rulers” has been synthesized to examine ligand binding to the M6P/IGF2R. The set is estimated to span a P-P distance range of 16–26 Å (MMFF energy minimization on the hydrated phosphonates). Key synthetic transformations include sugar triflate displ...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2007
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2862223/ https://ncbi.nlm.nih.gov/pubmed/18068981 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2007.11.094 |
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