High-Affinity Ligand Binding by Wild-Type:Mutant Heteromeric Complexes of the Mannose 6-Phosphate/Insulin-like Growth Factor II Receptors

The mannose 6-phosphate/insulin-like growth factor II receptor (M6P/IGF2R) has diverse ligand-binding properties contributing to its roles in lysosome biogenesis and growth suppression. Optimal receptor binding and internalization of mannose 6-phosphate (Man-6-P)-bearing ligands requires a dimeric s...

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Hauptverfasser: Hartman, Michelle A., Kreiling, Jodi L., Byrd, James C., MacDonald, Richard G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2748650/
https://ncbi.nlm.nih.gov/pubmed/19236480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1742-4658.2009.06917.x
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