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High-Affinity Ligand Binding by Wild-Type:Mutant Heteromeric Complexes of the Mannose 6-Phosphate/Insulin-like Growth Factor II Receptors
The mannose 6-phosphate/insulin-like growth factor II receptor (M6P/IGF2R) has diverse ligand-binding properties contributing to its roles in lysosome biogenesis and growth suppression. Optimal receptor binding and internalization of mannose 6-phosphate (Man-6-P)-bearing ligands requires a dimeric s...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2009
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2748650/ https://ncbi.nlm.nih.gov/pubmed/19236480 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1742-4658.2009.06917.x |
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