“Zipped Synthesis” by Cross-Metathesis Provides a Cystathionine β-Synthase Inhibitor that Attenuates Cellular H(2)S Levels and Reduces Neuronal Infarction in a Rat Ischemic Stroke Model

[Image: see text] The gaseous neuromodulator H(2)S is associated with neuronal cell death pursuant to cerebral ischemia. As cystathionine β-synthase (CBS) is the primary mediator of H(2)S biogenesis in the brain, it has emerged as a potential target for the treatment of stroke. Herein, a “zipped” ap...

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Detalhes bibliográficos
Publicado no:ACS Cent Sci
Main Authors: McCune, Christopher D., Chan, Su Jing, Beio, Matthew L., Shen, Weijun, Chung, Woo Jin, Szczesniak, Laura M., Chai, Chou, Koh, Shu Qing, Wong, Peter T.-H., Berkowitz, David B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2016
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4850510/
https://ncbi.nlm.nih.gov/pubmed/27163055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscentsci.6b00019
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