Hydrogen-Deuterium Exchange and Hydroxyl Radical Footprinting for Mapping Hydrophobic Interactions of Human Bromodomain with a Small Molecule Inhibitor

par Li, Ke Sherry, Bergman, Elizabeth, Beno, Brett R., Huang, Richard Y.-C., Deyanova, Ekaterina, Chen, Guodong, Gross, Michael L.
Publié dans J Am Soc Mass Spectrom (2019)

Resistance profile of the HIV-1 maturation inhibitor GSK3532795 in vitro and in a clinical study

par Dicker, Ira, Zhang, Sharon, Ray, Neelanjana, Beno, Brett R., Regueiro-Ren, Alicia, Joshi, Samit, Cockett, Mark, Krystal, Mark, Lataillade, Max
Publié dans PLoS One (2019)

Epitope and Paratope Mapping of PD-1/Nivolumab by Mass Spectrometry-based Hydrogen/Deuterium Exchange, Cross-linking, and Molecular Docking

par Zhang, Mengru Mira, Huang, Richard Y.-C., Beno, Brett R., Deyanova, Ekaterina G., Li, Jing, Chen, Guodong, Gross, Michael L.
Publié dans Anal Chem (2020)

An Integrated Approach for Determining a Protein-Protein Binding Interface in Solution and an Evaluation of HDX Kinetics for Adjudicating Candidate Docking Models

par Zhang, Mengru Mira, Beno, Brett R., Huang, Richard Y.-C., Adhikari, Jagat, Deyanova, Ekaterina G., Li, Jing, Chen, Guodong, Gross, Michael L.
Publié dans Anal Chem (2019)

Orthogonal Mass Spectrometry-Based Footprinting for Epitope Mapping and Structural Characterization: The IL-6 Receptor upon Binding of Protein Therapeutics

par Li, Ke Sherry, Chen, Guodong, Mo, Jingjie, Huang, Richard Y-C, Deyanova, Ekaterina G., Beno, Brett R., O’Neil, Steve R., Tymiak, Adrienne A., Gross, Michael L.
Publié dans Anal Chem (2017)

A Small Molecule Inhibitor Selectively Induces Apoptosis in Cells Transformed by High Risk Human Papilloma Viruses

par Sheaffer, Amy K., Lee, Min S., Qi, Huilin, Chaniewski, Susan, Zheng, Xiaofan, Farr, Glen A., Esposito, Kim, Harden, David, Lei, Ming, Schweizer, Liang, Friborg, Jacques, Agler, Michele, McPhee, Fiona, Gentles, Robert, Beno, Brett R., Chupak, Lou, Mason, Stephen
Publié dans PLoS One (2016)

High-Throughput Screening and Rapid Inhibitor Triage Using an Infectious Chimeric Hepatitis C Virus

par Wichroski, Michael J., Fang, Jie, Eggers, Betsy J., Rose, Ronald E., Mazzucco, Charles E., Pokornowski, Kevin A., Baldick, Carl J., Anthony, Monique N., Dowling, Craig J., Barber, Lauren E., Leet, John E., Beno, Brett R., Gerritz, Samuel W., Agler, Michele L., Cockett, Mark I., Tenney, Daniel J.
Publié 2012

Discovery of BMS-955176, a Second Generation HIV-1 Maturation Inhibitor with Broad Spectrum Antiviral Activity

par Regueiro-Ren, Alicia, Liu, Zheng, Chen, Yan, Sin, Ny, Sit, Sing-Yuen, Swidorski, Jacob J., Chen, Jie, Venables, Brian L., Zhu, Juliang, Nowicka-Sans, Beata, Protack, Tricia, Lin, Zeyu, Terry, Brian, Samanta, Himadri, Zhang, Sharon, Li, Zhufang, Beno, Brett R., Huang, Xiaohua S., Rahematpura, Sandhya, Parker, Dawn D., Haskell, Roy, Jenkins, Susan, Santone, Kenneth S., Cockett, Mark I., Krystal, Mark, Meanwell, Nicholas A., Hanumegowda, Umesh, Dicker, Ira B.
Publié dans ACS Med Chem Lett (2016)

Structure–Property Basis for Solving Transporter-Mediated Efflux and Pan-Genotypic Inhibition in HCV NS5B Inhibitors

par Yeung, Kap-Sun, Beno, Brett R., Mosure, Kathy, Zhu, Juliang, Grant-Young, Katherine A., Parcella, Kyle, Anjanappa, Prakash, Bora, Rajesh Onkardas, Selvakumar, Kumaravel, Wang, Ying-Kai, Fang, Hua, Krause, Rudolph, Rigat, Karen, Liu, Mengping, Lemm, Julie, Sheriff, Steven, Witmer, Mark, Tredup, Jeffrey, Jardel, Adam, Kish, Kevin, Parker, Dawn, Haskell, Roy, Santone, Kenneth, Meanwell, Nicholas A., Soars, Matthew G., Roberts, Susan B., Kadow, John F.
Publié dans ACS Med Chem Lett (2018)

The discovery of a pan-genotypic, primer grip inhibitor of HCV NS5B polymerase

par Eastman, Kyle J., Parcella, Kyle, Yeung, Kap-Sun, Grant-Young, Katharine A., Zhu, Juliang, Wang, Tao, Zhang, Zhongxing, Yin, Zhiwei, Beno, Brett R., Sheriff, Steven, Kish, Kevin, Tredup, Jeffrey, Jardel, Adam G., Halan, Vivek, Ghosh, Kaushik, Parker, Dawn, Mosure, Kathy, Fang, Hua, Wang, Ying-Kai, Lemm, Julie, Zhuo, Xiaoliang, Hanumegowda, Umesh, Rigat, Karen, Donoso, Maria, Tuttle, Maria, Zvyaga, Tatyana, Haarhoff, Zuzana, Meanwell, Nicholas A., Soars, Matthew G., Roberts, Susan B., Kadow, John F.
Publié dans Medchemcomm (2017)