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Hydrogen-Deuterium Exchange and Hydroxyl Radical Footprinting for Mapping Hydrophobic Interactions of Human Bromodomain with a Small Molecule Inhibitor

Mass spectrometry-based protein footprinting, a valuable structural tool in mapping protein-ligand interaction, has been extensively applied to protein-protein complexes, showing success in mapping large interfaces. Here we utilized an integrated footprinting strategy incorporating both hydrogen-deu...

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Detalhes bibliográficos
Publicado no:J Am Soc Mass Spectrom
Main Authors: Li, Ke Sherry, Bergman, Elizabeth, Beno, Brett R., Huang, Richard Y.-C., Deyanova, Ekaterina, Chen, Guodong, Gross, Michael L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6917846/
https://ncbi.nlm.nih.gov/pubmed/31720974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13361-019-02316-1
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