Orthogonal Mass Spectrometry-Based Footprinting for Epitope Mapping and Structural Characterization: The IL-6 Receptor upon Binding of Protein Therapeutics

Higher order structure (HOS) is a crucial determinant for the biological functions and quality attributes of protein therapeutics. Mass spectrometry (MS)-based protein footprinting approaches play an important role in elucidating the relationship between protein biophysical properties and structure....

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Publicado no:Anal Chem
Main Authors: Li, Ke Sherry, Chen, Guodong, Mo, Jingjie, Huang, Richard Y-C, Deyanova, Ekaterina G., Beno, Brett R., O’Neil, Steve R., Tymiak, Adrienne A., Gross, Michael L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5549780/
https://ncbi.nlm.nih.gov/pubmed/28621526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.analchem.7b01748
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