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Hydrogen-Deuterium Exchange and Hydroxyl Radical Footprinting for Mapping Hydrophobic Interactions of Human Bromodomain with a Small Molecule Inhibitor
Mass spectrometry-based protein footprinting, a valuable structural tool in mapping protein-ligand interaction, has been extensively applied to protein-protein complexes, showing success in mapping large interfaces. Here we utilized an integrated footprinting strategy incorporating both hydrogen-deu...
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| Publicat a: | J Am Soc Mass Spectrom |
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| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6917846/ https://ncbi.nlm.nih.gov/pubmed/31720974 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13361-019-02316-1 |
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