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An Integrated Approach for Determining a Protein-Protein Binding Interface in Solution and an Evaluation of HDX Kinetics for Adjudicating Candidate Docking Models
We describe an integrated approach of using hydrogen deuterium exchange mass spectrometry (HDX-MS), chemical crosslinking mass spectrometry (XL-MS), and molecular docking to characterize the binding interface and to predict the three-dimensional quaternary structure of a protein-protein complex in s...
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| 發表在: | Anal Chem |
|---|---|
| Main Authors: | , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2019
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7497726/ https://ncbi.nlm.nih.gov/pubmed/31710208 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.analchem.9b03879 |
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