Extracellular Vesicles and a Novel Form of Communication in the Brain

Por Basso, Manuela, Bonetto, Valentina
Publicado no Front Neurosci (2016)

Transglutaminase is a therapeutic target for oxidative stress, excitotoxicity and stroke: a new epigenetic kid on the CNS block

Por Basso, Manuela, Ratan, Rajiv R
Publicado em 2013

Looking Above but Not Beyond the Genome for Therapeutics in Neurology and Psychiatry: Epigenetic Proteins and RNAs Find a New Focus

Por Basso, Manuela, Sleiman, Sama, Ratan, Rajiv R.
Publicado em 2013

Histone Deacetylase Inhibitors and Mithramycin A Impact a Similar Neuroprotective Pathway at a Crossroad between Cancer and Neurodegeneration

Por Sleiman, Sama F., Berlin, Jill, Basso, Manuela, S.Karuppagounder, Saravanan, Rohr, Jürgen, Ratan, Rajiv R.
Publicado em 2011

Putting the ‘HAT’ back on survival signalling: the promises and challenges of HDAC inhibition in the treatment of neurological conditions

Por Sleiman, Sama F, Basso, Manuela, Mahishi, Lata, Kozikowski, Alan P, Donohoe, Mary E, Langley, Brett, Ratan, Rajiv R
Publicado em 2009

HIF Prolyl Hydroxylase Inhibitors Prevent Neuronal Death Induced by Mitochondrial Toxins: Therapeutic Implications for Huntington's Disease and Alzheimer's Disease

Por Niatsetskaya, Zoya, Basso, Manuela, Speer, Rachel E., McConoughey, Stephen J., Coppola, Giovanni, Ma, Thong C., Ratan, Rajiv R.
Publicado em 2010

In vitro Ischemia Suppresses Hypoxic Induction of Hypoxia Inducible Factor-1α by Inhibition of Synthesis and Not Enhanced Degradation

Por Karuppagounder, Saravanan S., Basso, Manuela, Sleiman, Sama F., Ma, Thong C., Speer, Rachel E., Smirnova, Natalya A., Gazaryan, Irina G., Ratan, Rajiv R.
Publicado no J Neurosci Res (2013)

Hypoxia inducible factor prolyl hydroxylases as targets for neuroprotection by “antioxidant” metal chelators: from ferroptosis to stroke

Por Speer, Rachel E., Karuppagounder, Saravanan S., Basso, Manuela, Sleiman, Sama, Kumar, Amit, Brand, David, Smirnova, Natalya, Gazaryan, Irina, Khim, Soah J., Ratan, Rajiv R.
Publicado no Free Radic Biol Med (2013)

Mutant Copper-Zinc Superoxide Dismutase (SOD1) Induces Protein Secretion Pathway Alterations and Exosome Release in Astrocytes: IMPLICATIONS FOR DISEASE SPREADING AND MOTOR NEURON...

Por Basso, Manuela, Pozzi, Silvia, Tortarolo, Massimo, Fiordaliso, Fabio, Bisighini, Cinzia, Pasetto, Laura, Spaltro, Gabriella, Lidonnici, Dario, Gensano, Francesco, Battaglia, Elisa, Bendotti, Caterina, Bonetto, Valentina
Publicado em 2013

Cu,Zn-Superoxide Dismutase Increases Toxicity of Mutant and Zinc-deficient Superoxide Dismutase by Enhancing Protein Stability

Por Sahawneh, Mary Anne, Ricart, Karina C., Roberts, Blaine R., Bomben, Valerie C., Basso, Manuela, Ye, Yaozu, Sahawneh, John, Franco, Maria Clara, Beckman, Joseph S., Estévez, Alvaro G.
Publicado em 2010

Utilization of an In Vivo Reporter for High Throughput Identification of Branched Small Molecule Regulators of Hypoxic Adaptation

Por Smirnova, Natalya A., Rakhman, Ilay, Moroz, Natalia, Basso, Manuela, Payappilly, Jimmy, Kazakov, Sergey, Hernandez-Guzman, Francisco, Gaisina, Irina N., Kozikowski, Alan P., Ratan, Rajiv R., Gazaryan, Irina G.
Publicado no Chem Biol (2010)

Hydroxamic Acid-Based Histone Deacetylase (HDAC) Inhibitors Can Mediate Neuroprotection Independent of HDAC Inhibition

Por Sleiman, Sama F., Olson, David E., Bourassa, Megan W., Karuppagounder, Saravanan S., Zhang, Yan-Ling, Gale, Jennifer, Wagner, Florence F., Basso, Manuela, Coppola, Giovanni, Pinto, John T., Holson, Edward B., Ratan, Rajiv R.
Publicado em 2014

Transglutaminase Inhibition Protects against Oxidative Stress-Induced Neuronal Death Downstream of Pathological ERK Activation

Por Basso, Manuela, Berlin, Jill, Xia, Li, Sleiman, Sama F., Ko, Brendan, Haskew-Layton, Renee, Kim, Eunhee, Antonyak, Marc A., Cerione, Richard A., Iismaa, Siiri E., Willis, Dianna, Cho, Sunghee, Ratan, Rajiv R.
Publicado em 2012

Development of Neh2-Luciferase Reporter and Its Application for High Throughput Screening and Real-Time Monitoring of Nrf2 Activators

Por Smirnova, Natalya A., Haskew-Layton, Renee E., Basso, Manuela, Hushpulian, Dmitry M., Payappilly, Jimmy B., Speer, Rachel E., Ahn, Young-Hoon, Rakhman, Ilay, Cole, Philip A., Pinto, John T., Ratan, Rajiv R., Gazaryan, Irina G.
Publicado em 2011

Characterization of Detergent-Insoluble Proteins in ALS Indicates a Causal Link between Nitrative Stress and Aggregation in Pathogenesis

Por Basso, Manuela, Samengo, Giuseppina, Nardo, Giovanni, Massignan, Tania, D'Alessandro, Giuseppina, Tartari, Silvia, Cantoni, Lavinia, Marino, Marianna, Cheroni, Cristina, De Biasi, Silvia, Giordana, Maria Teresa, Strong, Michael J., Estevez, Alvaro G., Salmona, Mario, Bendotti, Caterina, Bonetto, Valentina
Publicado em 2009

Antihelminthic Benzimidazoles Are Novel HIF Activators That Prevent Oxidative Neuronal Death via Binding to Tubulin

Por Aleyasin, Hossein, Karuppagounder, Saravanan S., Kumar, Amit, Sleiman, Sama, Basso, Manuela, Ma, Thong, Siddiq, Ambreena, Chinta, Shankar J., Brochier, Camille, Langley, Brett, Haskew-Layton, Renee, Bane, Susan L., Riggins, Gregory J., Gazaryan, Irina, Starkov, Anatoly A., Andersen, Julie K., Ratan, Rajiv R.
Publicado no Antioxid Redox Signal (2015)

Protein Arginine Methyltransferase 6 Enhances Polyglutamine-Expanded Androgen Receptor Function and Toxicity in Spinal and Bulbar Muscular Atrophy

Por Scaramuzzino, Chiara, Casci, Ian, Parodi, Sara, Lievens, Patricia M.J., Polanco, Maria J., Milioto, Carmelo, Chivet, Mathilde, Monaghan, John, Mishra, Ashutosh, Badders, Nisha, Aggarwal, Tanya, Grunseich, Christopher, Sambataro, Fabio, Basso, Manuela, Fackelmayer, Frank O., Taylor, J. Paul, Pandey, Udai Bhan, Pennuto, Maria
Publicado no Neuron (2015)

Mithramycin Is a Gene-Selective Sp1 Inhibitor That Identifies a Biological Intersection between Cancer and Neurodegeneration

Por Sleiman, Sama F., Langley, Brett C., Basso, Manuela, Berlin, Jill, Xia, Li, Payappilly, Jimmy B., Kharel, Madan K., Guo, Hengchang, Marsh, J. Lawrence, Thompson, Leslie Michels, Mahishi, Lata, Ahuja, Preeti, MacLellan, W. Robb, Geschwind, Daniel H., Coppola, Giovanni, Rohr, Jürgen, Ratan, Rajiv R.
Publicado em 2011

Nitration of Hsp90 induces cell death

Por Franco, Maria Clara, Ye, Yaozu, Refakis, Christian A., Feldman, Jessica L., Stokes, Audrey L., Basso, Manuela, Melero Fernández de Mera, Raquel M., Sparrow, Nicklaus A., Calingasan, Noel Y., Kiaei, Mahmoud, Rhoads, Timothy W., Ma, Thong C., Grumet, Martin, Barnes, Stephen, Beal, M. Flint, Beckman, Joseph S., Mehl, Ryan, Estévez, Alvaro G.
Publicado em 2013

A Selective Phenelzine Analogue Inhibitor of Histone Demethylase LSD1

Por Prusevich, Polina, Kalin, Jay H., Ming, Shonoi A., Basso, Manuela, Givens, Jeffrey, Li, Xin, Hu, Jianfei, Taylor, Martin S., Cieniewicz, Anne M., Hsiao, Po-Yuan, Huang, Rong, Roberson, Heather, Adejola, Nkosi, Avery, Lindsay B., Casero, Robert A., Taverna, Sean D., Qian, Jiang, Tackett, Alan J., Ratan, Rajiv R., McDonald, Oliver G., Feinberg, Andrew P., Cole, Philip A.
Publicado em 2014