Hydroxamic Acid-Based Histone Deacetylase (HDAC) Inhibitors Can Mediate Neuroprotection Independent of HDAC Inhibition

Histone deacetylase (HDAC) inhibition improves function and extends survival in rodent models of a host of neurological conditions, including stroke, and neurodegenerative diseases. Our understanding, however, of the contribution of individual HDAC isoforms to neuronal death is limited. In this stud...

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Huvudupphovsmän: Sleiman, Sama F., Olson, David E., Bourassa, Megan W., Karuppagounder, Saravanan S., Zhang, Yan-Ling, Gale, Jennifer, Wagner, Florence F., Basso, Manuela, Coppola, Giovanni, Pinto, John T., Holson, Edward B., Ratan, Rajiv R.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Society for Neuroscience 2014
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Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4205555/
https://ncbi.nlm.nih.gov/pubmed/25339746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1010-14.2014
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