Hypoxia-inducible factor prolyl hydroxylase inhibition: robust new target or another big bust for stroke therapeutics?

av Karuppagounder, Saravanan S, Ratan, Rajiv R
Publicerad 2012

Oxidant Induced Changes in Mitochondria and Calcium Dynamicsin the Pathophysiology of Alzheimer's Disease

av Gibson, Gary E., Karuppagounder, Saravanan S., Shi, Qingli
Publicerad 2008

Changes in Inflammatory Processes Associated With Selective Vulnerability Following Mild Impairment of Oxidative Metabolism

av Karuppagounder, Saravanan S., Shi, Qingli, Xu, Hui, Gibson, Gary E.
Publicerad 2007

Epigenetic Regulators of Neuronal Ferroptosis Identify Novel Therapeutics for Neurological diseases: HDACs, Transglutaminases, and HIF prolyl hydroxylases

av Rroji, Orjon, Kumar, Amit, Karuppagounder, Saravanan S., Ratan, Rajiv R.
I publikationen Neurobiol Dis (2020)

The interferon response as a common final pathway for many preconditioning stimuli: unexpected crosstalk between hypoxic adaptation and antiviral defense

av Karuppagounder, Saravanan S., Zhai, Yujia, Chen, Yingxin, He, Rongrong, Ratan, Rajiv R.
I publikationen Cond Med (2018)

Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer’s Disease

av Karuppagounder, Saravanan S., Pinto, John T., Xu, Hui, Chen, Lian H., Beal, M. Flint, Gibson, Gary E.
Publicerad 2008

Histone Deacetylase Inhibitors and Mithramycin A Impact a Similar Neuroprotective Pathway at a Crossroad between Cancer and Neurodegeneration

av Sleiman, Sama F., Berlin, Jill, Basso, Manuela, S.Karuppagounder, Saravanan, Rohr, Jürgen, Ratan, Rajiv R.
Publicerad 2011

The Epigenetics of Stroke Recovery and Rehabilitation: From Polycomb to Histone Deacetylases

av Elder, Jessica, Cortes, Mar, Rykman, Avrielle, Hill, Justin, Karuppagounder, Saravanan, Edwards, Dylan, Ratan, Rajiv R.
Publicerad 2013

Translocation of Amyloid Precursor Protein C-terminal fragment(s) to the nucleus precedes neuronal death due to thiamine deficiency induced mild impairment of oxidative metabolism

av Karuppagounder, Saravanan S., Xu, Hui, Pechman, David, Chen, Lian H., DeGiorgio, Lorraine A., Gibson, Gary E.
Publicerad 2008

The drug adaptaquin blocks ATF4/CHOP-dependent pro-death Trib3 induction and protects in cellular and mouse models of Parkinson’s disease

av Aimé, Pascaline, Karuppagounder, Saravanan S., Rao, Apeksha, Chen, Yingxin, Burke, Robert E., Ratan, Rajiv R., Greene, Lloyd A.
I publikationen Neurobiol Dis (2020)

Metabolism and epigenetics in the nervous system: Creating cellular fitness and resistance to neuronal death in neurological conditions via modulation of oxygen-, iron-, and 2-oxog...

av Karuppagounder, Saravanan S., Kumar, Amit, Shao, Diana S., Zille, Marietta, Bourassa, Megan W., Caulfield, Joseph T., Alim, Ishraq, Ratan, Rajiv R.
I publikationen Brain Res (2015)

Ferroptosis in Neurons and Cancer Cells Is Similar But Differentially Regulated by Histone Deacetylase Inhibitors

av Zille, Marietta, Kumar, Amit, Kundu, Nandini, Bourassa, Megan W., Wong, Victor S. C., Willis, Dianna, Karuppagounder, Saravanan S., Ratan, Rajiv R.
I publikationen eNeuro (2019)

In vitro Ischemia Suppresses Hypoxic Induction of Hypoxia Inducible Factor-1α by Inhibition of Synthesis and Not Enhanced Degradation

av Karuppagounder, Saravanan S., Basso, Manuela, Sleiman, Sama F., Ma, Thong C., Speer, Rachel E., Smirnova, Natalya A., Gazaryan, Irina G., Ratan, Rajiv R.
I publikationen J Neurosci Res (2013)

Hypoxia inducible factor prolyl hydroxylases as targets for neuroprotection by “antioxidant” metal chelators: from ferroptosis to stroke

av Speer, Rachel E., Karuppagounder, Saravanan S., Basso, Manuela, Sleiman, Sama, Kumar, Amit, Brand, David, Smirnova, Natalya, Gazaryan, Irina, Khim, Soah J., Ratan, Rajiv R.
I publikationen Free Radic Biol Med (2013)

Thiamine deficiency induces oxidative stress and exacerbates the plaque pathology in Alzheimer’s mouse model

av Karuppagounder, Saravanan S., Xu, Hui, Shi, Qingli, Chen, Lian H., Pedrini, Steve, Pechman, David, Baker, Harriet, Beal, M. Flint, Gandy, Sam E., Gibson, Gary E.
Publicerad 2008

Neuronal Death After Hemorrhagic Stroke In Vitro and In Vivo Shares Features of Ferroptosis and Necroptosis

av Zille, Marietta, Karuppagounder, Saravanan S., Chen, Yingxin, Gough, Peter J., Phil, D., Bertin, John, Finger, Joshua, Milner, Teresa A., Jonas, Elizabeth A., Ratan, Rajiv R.
I publikationen Stroke (2017)

Hypoxia-inducible factor prolyl hydroxylase domain (PHD) inhibition after contusive spinal cord injury does not improve locomotor recovery

av Wei, George Z., Saraswat Ohri, Sujata, Khattar, Nicolas K., Listerman, Adam W., Doyle, Catherine H., Andres, Kariena R., Karuppagounder, Saravanan S., Ratan, Rajiv R., Whittemore, Scott R., Hetman, Michal
I publikationen PLoS One (2021)

Hydroxamic Acid-Based Histone Deacetylase (HDAC) Inhibitors Can Mediate Neuroprotection Independent of HDAC Inhibition

av Sleiman, Sama F., Olson, David E., Bourassa, Megan W., Karuppagounder, Saravanan S., Zhang, Yan-Ling, Gale, Jennifer, Wagner, Florence F., Basso, Manuela, Coppola, Giovanni, Pinto, John T., Holson, Edward B., Ratan, Rajiv R.
Publicerad 2014

Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate

av Sleiman, Sama F, Henry, Jeffrey, Al-Haddad, Rami, El Hayek, Lauretta, Abou Haidar, Edwina, Stringer, Thomas, Ulja, Devyani, Karuppagounder, Saravanan S, Holson, Edward B, Ratan, Rajiv R, Ninan, Ipe, Chao, Moses V
I publikationen eLife (2016)

Antihelminthic Benzimidazoles Are Novel HIF Activators That Prevent Oxidative Neuronal Death via Binding to Tubulin

av Aleyasin, Hossein, Karuppagounder, Saravanan S., Kumar, Amit, Sleiman, Sama, Basso, Manuela, Ma, Thong, Siddiq, Ambreena, Chinta, Shankar J., Brochier, Camille, Langley, Brett, Haskew-Layton, Renee, Bane, Susan L., Riggins, Gregory J., Gazaryan, Irina, Starkov, Anatoly A., Andersen, Julie K., Ratan, Rajiv R.
I publikationen Antioxid Redox Signal (2015)