Hydroxamate-based Histone Deacetylase Inhibitors Can Protect Neurons from Oxidative Stress via an HDAC-independent Catalase-like Mechanism

Histone deacetylase (HDAC) inhibitors have shown enormous promise for treating various disease states, presumably due to their ability to modulate acetylation of histone and non-histone proteins. Many of these inhibitors contain functional groups capable of strongly chelating metal ions. We demonstr...

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Udgivet i:Chem Biol
Main Authors: Olson, David E., Sleiman, Sama F., Bourassa, Megan W., Wagner, Florence F., Gale, Jennifer P., Zhang, Yan-Ling, Ratan, Rajiv R., Holson, Edward B.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4562013/
https://ncbi.nlm.nih.gov/pubmed/25892200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2015.03.014
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