Hydroxamate-based Histone Deacetylase Inhibitors Can Protect Neurons from Oxidative Stress via an HDAC-independent Catalase-like Mechanism

Histone deacetylase (HDAC) inhibitors have shown enormous promise for treating various disease states, presumably due to their ability to modulate acetylation of histone and non-histone proteins. Many of these inhibitors contain functional groups capable of strongly chelating metal ions. We demonstr...

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :Chem Biol
Главные авторы: Olson, David E., Sleiman, Sama F., Bourassa, Megan W., Wagner, Florence F., Gale, Jennifer P., Zhang, Yan-Ling, Ratan, Rajiv R., Holson, Edward B.
Формат: Artigo
Язык:Inglês
Опубликовано: 2015
Предметы:
Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4562013/
https://ncbi.nlm.nih.gov/pubmed/25892200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2015.03.014
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы