Cu,Zn-Superoxide Dismutase Increases Toxicity of Mutant and Zinc-deficient Superoxide Dismutase by Enhancing Protein Stability

When replete with zinc and copper, amyotrophic lateral sclerosis (ALS)-associated mutant SOD proteins can protect motor neurons in culture from trophic factor deprivation as efficiently as wild-type SOD. However, the removal of zinc from either mutant or wild-type SOD results in apoptosis of motor n...

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Main Authors: Sahawneh, Mary Anne, Ricart, Karina C., Roberts, Blaine R., Bomben, Valerie C., Basso, Manuela, Ye, Yaozu, Sahawneh, John, Franco, Maria Clara, Beckman, Joseph S., Estévez, Alvaro G.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Molecular Bases of Disease
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2962488/
https://ncbi.nlm.nih.gov/pubmed/20663894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.118901
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