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Structural Characterization of Zinc-deficient Human Superoxide Dismutase and Implications for ALS
Over 130 mutations to copper, zinc superoxide dismutase (SOD) are implicated in the selective death of motor neurons found in 25% of familial amyotrophic lateral sclerosis (ALS) patients. Despite their widespread distribution, ALS mutations appear positioned to cause structural and misfolding defect...
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| Hauptverfasser: | , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2007
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2175016/ https://ncbi.nlm.nih.gov/pubmed/17888947 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2007.07.043 |
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