Structural Characterization of Zinc-deficient Human Superoxide Dismutase and Implications for ALS

Over 130 mutations to copper, zinc superoxide dismutase (SOD) are implicated in the selective death of motor neurons found in 25% of familial amyotrophic lateral sclerosis (ALS) patients. Despite their widespread distribution, ALS mutations appear positioned to cause structural and misfolding defect...

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Autors principals: Roberts, Blaine R., Tainer, John A., Getzoff, Elizabeth D., Malencik, Dean A., Anderson, Sonia R., Bomben, Valerie C., Meyers, Kathrin R., Karplus, P. Andrew, Beckman, Joseph S.
Format: Artigo
Idioma:Inglês
Publicat: 2007
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2175016/
https://ncbi.nlm.nih.gov/pubmed/17888947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2007.07.043
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