Utilization of an In Vivo Reporter for High Throughput Identification of Branched Small Molecule Regulators of Hypoxic Adaptation

Small molecules inhibiting hypoxia inducible factor (HIF) prolyl hydroxylases (PHDs) are the focus of drug development efforts directed toward the treatment of ischemia and metabolic imbalance. A cell-based reporter produced by fusing HIF-1α oxygen degradable domain (ODD) to luciferase was shown to...

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Veröffentlicht in:Chem Biol
Hauptverfasser: Smirnova, Natalya A., Rakhman, Ilay, Moroz, Natalia, Basso, Manuela, Payappilly, Jimmy, Kazakov, Sergey, Hernandez-Guzman, Francisco, Gaisina, Irina N., Kozikowski, Alan P., Ratan, Rajiv R., Gazaryan, Irina G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4327942/
https://ncbi.nlm.nih.gov/pubmed/20416509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2010.03.008
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