Utilization of an In Vivo Reporter for High Throughput Identification of Branched Small Molecule Regulators of Hypoxic Adaptation

Small molecules inhibiting hypoxia inducible factor (HIF) prolyl hydroxylases (PHDs) are the focus of drug development efforts directed toward the treatment of ischemia and metabolic imbalance. A cell-based reporter produced by fusing HIF-1α oxygen degradable domain (ODD) to luciferase was shown to...

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Detalhes bibliográficos
Publicado no:Chem Biol
Main Authors: Smirnova, Natalya A., Rakhman, Ilay, Moroz, Natalia, Basso, Manuela, Payappilly, Jimmy, Kazakov, Sergey, Hernandez-Guzman, Francisco, Gaisina, Irina N., Kozikowski, Alan P., Ratan, Rajiv R., Gazaryan, Irina G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4327942/
https://ncbi.nlm.nih.gov/pubmed/20416509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2010.03.008
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