Activation of Nrf2 and Hypoxic Adaptive Response Contribute to Neuroprotection Elicited by Phenylhydroxamic Acid Selective HDAC6 Inhibitors

Activation of HIF-1α and Nrf2 is a primary component of cellular response to oxidative stress, and activation of HIF-1α and Nrf2 provides neuroprotection in models of neurodegenerative disorders, including ischemic stroke, Alzheimer’s and Parkinson’s diseases. Screening a library of CNS-targeted dru...

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Gepubliceerd in:ACS Chem Neurosci
Hoofdauteurs: Gaisina, Irina N., Lee, Sue H., Kaidery, Navneet A., Ben Aissa, Manel, Ahuja, Manuj, Smirnova, Natalya N., Wakade, Sushama, Gaisin, Arsen, Bourassa, Megan W., Ratan, Rajiv R., Nikulin, Sergey V., Poloznikov, Andrey A., Thomas, Bobby, Thatcher, Gregory R. J., Gazaryan, Irina G.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5955769/
https://ncbi.nlm.nih.gov/pubmed/29338172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.7b00435
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