Distinct Nrf2 Signaling Mechanisms of Fumaric Acid Esters and Their Role in Neuroprotection against 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Experimental Parkinson's-Like Disease

A promising approach to neurotherapeutics involves activating the nuclear-factor-E2-related factor 2 (Nrf2)/antioxidant response element signaling, which regulates expression of antioxidant, anti-inflammatory, and cytoprotective genes. Tecfidera, a putative Nrf2 activator, is an oral formulation of...

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Pubblicato in:J Neurosci
Autori principali: Ahuja, Manuj, Ammal Kaidery, Navneet, Yang, Lichuan, Calingasan, Noel, Smirnova, Natalya, Gaisin, Arsen, Gaisina, Irina N., Gazaryan, Irina, Hushpulian, Dmitry M., Kaddour-Djebbar, Ismail, Bollag, Wendy B., Morgan, John C., Ratan, Rajiv R., Starkov, Anatoly A., Beal, M. Flint, Thomas, Bobby
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2016
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4899530/
https://ncbi.nlm.nih.gov/pubmed/27277809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0426-16.2016
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